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Hip fracture is
among the most common injuries necessitating hospital admission. Fractures of
the hip include fractures of the proximal femur and pelvic ring and may be
classified as pathologic or nonpathologic. Regardless of the type of fracture,
however, hip fractures can lead to substantial morbidity and mortality.
This
article discusses the epidemiology of fractures of the proximal femur and the
evaluation and treatment of nonpathologic and osteoporotic pathologic proximal
femoral fractures. The specific types of proximal femoral fracture discussed
are intertrochanteric, femoral neck, subtrochanteric, and greater trochanteric
fractures. A future article in this journal will discuss fractures of the
pelvic ring, including sacral and acetabular injuries.
EPIDEMIOLOGY OF
PROXIMAL FEMORAL FRACTURES
Between 220,000
and 250,000 proximal femoral fractures occur in the United States each year1,2;
90% of these fractures occur in patients older than 50 years.1,2 In
younger patients, proximal femoral fractures are usually the result of
high-energy physical trauma (e.g., high-speed motor vehicle accidents) and
usually occur in the absence of disease. Intertrochanteric and femoral neck
fractures account for 90% of the proximal femoral fractures occurring in
elderly patients.1 Proximal femoral fractures in elderly patients
are often pathologic, usually resulting from minimal-to-moderate physical
trauma to areas of bone significantly affected by osteoporosis. However,
pathologic fractures can occur at any age; typically, these fractures result
from low-energy injuries and may be characterized by unusual fracture
patterns.3
The incidence of proximal femoral fractures
among females is 2 to 3 times higher than the incidence of such fractures
among males.1 Also, the risk of sustaining a proximal femoral
fracture doubles every 10 years after age 50 years.1 Other risk
factors for proximal femoral fractures include osteoporosis,1 a
maternal history of hip fractures,4 excessive alcohol consumption,5
high caffeine intake,5 physical inactivity,6 low
body weight,7 previous hip fracture,8 the use of certain
psychotropic medications,9 visual impairment,4 dementia,10
residence in an institution,11 and smoking.12
INITIAL EVALUATION
The evaluation of a
patient who definitely or potentially has a hip fracture involves reviewing
the patient’s medical history, performing a physical examination, and carrying
out radiographic studies. The radiographic studies are used to determine the
exact location (Figure 1) and degree of displacement of the fracture;
this information can help clinicians to differentiate the various subtypes of
proximal femoral fracture (e.g., intertrochanteric, femoral neck,
subtrochanteric, greater trochanteric).
The patient’s symptoms
and the physical examination findings usually depend on the type of fracture
and its degree of displacement. For most proximal femoral fractures,
ecchymosis generally appears during the first few days after the fractures
occur. However, ecchymosis may not develop with femoral neck fractures because
the fracture hematoma may be contained within the hip capsule.
Fractures of the
proximal femur that are incomplete or nondisplaced may cause only minimal pain
with movement and weight bearing. However, clinical evidence of such fractures
can be obtained by using the Stinchfield test.12 With this test,
the patient lies in a supine position and attempts to lift the affected leg
against gravity and then against weight resistance. If groin or thigh pain is
elicited during either of these exercises, the test is positive. Patients with
displaced fractures of the proximal femur usually cannot bear weight and
report pain with even slight movement of the affected extremity. The displaced
fracture usually causes the leg to shorten and become abducted and externally
rotated to some degree.13 Furthermore, there may be pain or
crepitation with palpation of the lateral femur and trochanter.
Most fractures of
the proximal femur can be observed on plain radiographs. Standard views
include an anteroposterior (AP) view of the pelvis and a true lateral view of
the hip. With respect to hard-to-see fractures, another view that may be
helpful is an AP view obtained with the hip internally rotated approximately
15 degrees.13 Magnetic resonance imaging (MRI) and technetium bone
scans may also prove useful. Although bone scans have a high sensitivity in
diagnosing fractures 48 to 72 hours after they occur, MRI has been found to be
100% sensitive, can be used to identify fractures sooner, and is very useful
for finding occult fractures.3 Patients with acute hip pain and
normal results on plain radiographs must be assumed to have a hip fracture
until proven otherwise; MRI or a technetium bone scan may be needed to confirm
the diagnosis of a symptomatic, nondisplaced fracture.14–21 If the
hip joint is irritable on physical examination, limited MRI is the best
technique to confirm a fracture within the first 2 to 3 days after it is
thought to have occurred. If the patient’s pain is more diffuse, a technetium
bone scan of the pelvis, lumbar spine, and hips may be preferred; a 3-day
interval between the injury and the performance of this test is necessary to
allow sufficient sensitivity. During this 3-day period, patients should
practice protected weight bearing and should receive treatment for pain.
GENERAL TREATMENT
CONSIDERATIONS
The goal of treatment is to limit pain
and to help the patient return to the level of activity he or she had prior to
sustaining the fracture. Efforts to attain this goal may or may not involve
surgery. Non-operative treatment is usually reserved for impacted or
nondisplaced proximal femoral fractures. The premise behind non-operative
treatment is that if the patient can be mobilized and his or her pain
controlled, the risk of complications such as skin breakdown and pulmonary
illness is decreased. However, the risk of displacement of the fracture must
also be considered. In cases of femoral neck fractures, operative treatment is
favored to avoid displacement and possible avascular necrosis of the hip. For
most proximal femoral fractures, operative treatment is more appropriate.
 |
Figure 1.
Anatomic regions relating to areas of proximal femoral fractures.
|
Although hip fractures in young patients
may be complicated by medical issues, surgical treatment for these individuals
is typically emergent. However, for elderly patients, who sometimes have
cardiac, pulmonary, and psychiatric co-morbidities, an immediate surgical
procedure may initially carry too high a risk for substantial morbidity and
mortality. Prior to surgery, elderly patients need to be medically evaluated
to minimize any potential risks of surgery. Medical work-up usually involves
evaluating the patient for hypertension, heart disease (including coronary
artery disease, dysrhythmias, and congestive heart failure), diabetes
mellitus, chronic obstructive pulmonary disease, cerebral vascular disease,
and urinary tract infection.
The time needed to perform a complete
medical evaluation and treat or manage co-morbidities in elderly patients can
delay surgery for at least 12 to 24 hours.7 Although there is
conflicting evidence about the mortality rate if surgery is delayed for 24
hours or less, there is substantial evidence suggesting that if surgery is
postponed for more than 3 days, the mortality rate within the first year after
this treatment doubles.3,22–27 It may be true, however, that the
patients who experience a delay of more than 3 days in undergoing their
surgical procedure are the most ill on presentation. Furthermore, prolonging
the time before surgery increases the risk of skin breakdown, urinary tract
infection, deep vein thrombosis (DVT), and pulmonary complications.1
Moreover, if a patient, regardless of age, is
receiving anticoagulation therapy because of atrial fibrillation, valve
replacement, history of transient ischemic attacks, or other reasons, reversal
of this therapy may be appropriate before the surgical procedure is performed.
In general, anticoagulation therapy can be reversed by administering fresh
frozen plasma or vitamin K (i.e., phytonadione). However, fresh frozen plasma
is usually transient in its effect and can be associated with transfusion
reactions and other problems. Moreover, reversal of the anticoagulative effect
of warfarin with vitamin K can be complicated by thrombosis, and doses of
vitamin K greater than 10 mg can lead to warfarin resistance for as long as a
week.25 If a patient has been receiving warfarin, the prothrombin
time and international normalized ratio (INR) can be allowed to normalize by
simply discontinuing the warfarin. In patients with a history of transient
ischemic attacks, cardiomyopathy, and atrial fibrillation, discontinuation of
warfarin is unlikely to lead to an adverse event.26 However, in
patients with prosthetic heart valves whose warfarin anticoagulation therapy
is being reversed, unfractionated heparin should be administered as the INR
decreases to an acceptable level; the heparin can then be discontinued hours
prior to surgery.26
Prior to surgery for
hip fractures, most patients—irrespective of age—are confined to bed. During
this time, they most likely will require an analgesic agent, which can
contribute to the increased mental status changes seen in elderly patients. To
help with the discomfort of a displaced fracture, 5 lb of longitudinal
(Buck’s) skin traction can be used, although pillow support alone has been
shown to be just as effective.28 If surgery is delayed for a
considerable amount of time, DVT prophylaxis is indicated and can include
graduated compression stockings; sequential pneumatic calf, thigh, or ankle
pumps; and low-molecular-weight heparin.
INTERTROCHANTERIC
FRACTURES
General
Characteristics
Intertrochanteric
fractures occur in the transitional bone between the femoral neck and the
femoral shaft (Figure 1).27 These fractures may involve both the
greater and the lesser trochanters. Transitional bone is composed of cortical
and trabecular bone. These bone types form the calcar femorale posteromedially,
which provides the strength to distribute the stresses of weight bearing.
Consequently, the stability of intertrochanteric fractures depends on the
preservation of the postero-medial cortical buttress.29
Osteonecrosis is uncommon because these fractures usually do not disturb the
femoral head blood supply. Moreover, because transitional bone is highly
vascular, complications such as nonunions are uncommon as well.27
Classification
The most often used
classification system for intertrochanteric fractures is based on the
stability of the fracture pattern and the ease in achieving a stable
reduction.27 This classification was introduced by Evans in 1949
and accurately differentiates stable fractures (standard oblique fracture
pattern) from unstable fractures (reverse oblique fracture pattern) (Figure
2). It is important to identify a reverse oblique fracture because this
type of fracture should not be treated with a standard compression plate. The
stability of intertrochanteric fractures depends on the integrity of the
posteromedial cortex, and instability increases with comminution of the
fracture, extension of the fracture into the sub-trochanteric region, and the
presence of a reverse oblique fracture pattern.27
 |
Figure 2. Simplified Evans’ classification
of intertrochanteric fractures: standard oblique fracture (stable) and
reverse oblique fracture (unstable). |
Treatment
Surgery is the mainstay
of treatment for both displaced and nondisplaced intertrochanteric fractures.
The primary reason for surgery is to allow the early mobilization of the
patient, with partial weight-bearing restrictions depending on the stability
of the reduction.27 The most common internal fixation device used
today is the sliding screw-plate device (Figure 3).27 This
implant consists of a large lag screw placed in the center of the femoral neck
and head and a side plate along the lateral femur. The screw-plate interface
angle is variable and depends on the anatomy of the patient and the fracture.
The advantage of the sliding lag screw, compared with a static screw, is that
it allows for impaction of the fragments; this impaction increases the
bone-on-bone contact, promoting osseous healing while decreasing implant
stress.27 The disadvantage is common shortening and rotation at the
fracture site.
 |
Although repair of an intertrochanteric
fracture is often referred to as open reduction with internal fixation
(ORIF), the term closed reduction with internal fixation (CRIF) may be
more accurate. The patient rests in a supine position on a fracture table that
allows the affected leg to be placed in traction. The fracture is anatomically
reduced by longitudinal traction and rotation of the leg.27 An
incision is made, and after the bone is exposed, the lag screw is placed into
the center of the femoral neck and head with fluoroscopic guidance. Optimally,
the end of the lag screw should be placed in close proximity to the apex of
the femoral head so that the sum of the distances between the end of the screw
and the apex of the femoral head in the AP and lateral views is less than 20
to 25 mm.30,31 By doing this, the occurrence of the complication
known as “cut out” of the lag screw from the femoral head can be almost
completely prevented.30,31 The next step is placement of the
sliding side plate device, which is fixed to the shaft of the femur by using
cortical screws.
CRIF of
intertrochanteric fractures may allow for immediate weight bearing.27
Depending on the stability of the fracture and its fixation, touchdown
weight bearing or partial weight bearing is usually recommended for 4 to 6
weeks after the surgical procedure. When signs of healing are apparent and
fracture collapse has diminished, weight-bearing status is usually increased.
Long-term problems after these fractures are healed include malrotation,
abductor muscle biomechanical abnormalities, pain (owing to the hardware), and
shortening of the leg at the fracture site (because of collapse). |
|
Figure 3. Radiograph (anteroposterior
view) of an inter-trochanteric fracture treated by way of internal
fixation with a lag screw and side plate. |
FEMORAL NECK
FRACTURES
General
Characteristics
Femoral neck fractures
occur between the end of the articular surface of the femoral head and the
inter-trochanteric region (Figure 1).32 These fractures are
intracapsular, and hip synovial fluid may interfere with their healing.3
Healing may also be affected by disruption of the arterial blood supply
to the fracture site and the femoral head; with femoral neck fractures, the
lateral ascending cervical branches of the medial femoral circumflex artery
are at risk for disruption. Loss of this blood supply increases the risk of
nonunion at the fracture site and the risk for avascular necrosis of the
femoral head.
 |
Figure 4. Garden classification system
of femoral neck fractures. (A) Garden I fracture: incomplete and
minimally displaced. The fracture shown is impacted and is in valgus
malalignment. (B) Garden II fracture: complete, nondisplaced. (C)
Garden III fracture: complete fracture and partially displaced. The
fracture shown is in varus malalignment. (D) Garden IV fracture:
completely displaced, with no engagement of the 2 principal fragments. |
Classification
The most commonly used
classification system for femoral neck fractures is the Garden system (Figure
4).3 The Garden system is based on the amount of displacement
of the fractures. Garden I fractures are minimally displaced and incomplete
and are usually impacted with the femoral head tilting in the posterolateral
direction. Garden II fractures are complete but nondisplaced. Garden III
fractures are complete and partially displaced, and Garden IV fractures are
completely displaced.3 Although the Garden system is the most
commonly used system of classification, there is much inter-observer
variability.3
Treatment
Operative treatment is favored for
femoral neck fractures. The specific type of operative treatment depends on
the age of the patient and the characteristics of the fracture (eg, location,
displacement, degree of comminution).1 In young patients, it is
necessary to obtain reduction of the femoral neck fracture as soon as possible
to decrease the risk of avascular necrosis.3 Anatomic reduction and
subsequent fixation are the goals of surgery. Young patients usually undergo
closed or open reduction, with percutaneous placement of 3 parallel cannulated
lag screws (Figure 5). The procedure is performed with the patient in a
supine position on a fracture table. The parallel cannulated lag screws allow
compression at the fracture site and maintain reduction while the fracture
heals. Elderly patients who have Garden I or II fractures also benefit from
parallel cannulated screw fixation, although this is usually performed in
situ. Hemiarthroplasty is the procedure of choice for elderly patients
with displaced femoral neck fractures. The previous activity level of the
patient is important in determining the exact type of hemiarthroplasty to
perform.3 Independent ambulators benefit from a cemented
hemiarthroplasty, because pain after surgery and component loosening are
minimal with this approach. Hemiarthroplasty is most often performed with
patients in the lateral decubitus position. After the incision is made and the
joint exposed, the femoral head is extracted and the femoral neck is cut to
allow placement of the prosthesis. There are many different prosthetic
devices, ranging from unipolar devices (including the Austin-Moore prosthesis)
to bipolar devices (Figure 6). The majority of these prostheses are
cemented; however, in elderly patients, who usually have compromised
cardiopulmonary reserves, excessive pressurization of the cement is avoided to
prevent further metabolic and mechanical insult.3
 |
 |
Figure 5. (A) Radiograph
(anteroposterior view) of a valgus, impacted (Garden I) femoral neck
fracture treated by way of internal fixation with 3 parallel
cannulated lag screws. (B) Schematic representation of screw
configuration as viewed from the side.
|
Figure 6. Radiograph (anteroposterior
view) of a displaced femoral neck fracture treated by way of femoral
head replacement with a bipolar prosthetic device.
|
Weight bearing after
surgery for patients of all ages is dependent on the fracture type, patient
demands and compliance, and surgeon preference. In general, patients who have
undergone reduction and fixation with cannulated lag screws usually have a
restricted weight-bearing status after the procedure. In contrast, patients
who have undergone hemiarthroplasty can be allowed to bear weight as
tolerated; certain restrictions of position are encouraged to prevent
dislocation.
SUBTROCHANTERIC
FRACTURES
General
Characteristics
Subtrochanteric
fractures occur between the lesser trochanter and the isthmus of the diaphysis
of the femur (Figure 1).3 These fractures are less common than
femoral neck and intertrochanteric fractures.
Classification
Classification systems
for subtrochanteric fractures have evolved in relation to the development of
new treatment devices. Early classification systems were based on the location
of the fracture and the number of fracture fragments.3 With the
advent of special intramedullary rods that can be used to treat these
fractures, the Russell-Taylor classification system was established.
The Russell-Taylor
system is based on the lesser trochanter continuity and whether the fracture
extends posteriorly into the greater trochanter and involves the piriformis
fossa (Figure 7)3; this system comprises 2 types of
fractures. These fracture types can be differentiated on the basis of the
appropriate use of the intramedullary nail. For type I fractures, which do not
extend into the piriformis fossa, closed intramedullary nailing has the
advantage of minimizing vascular compromise of the fragments.3 In
contrast, type II fractures involve the greater trochanter and the piriformis
fossa, making use of closed intramedullary nailing less favorable.3
 |
Figure 7. Russell-Taylor classification
of subtrochanteric fractures. Type I fractures do not extend into the
piriformis fossa, and thus, intramedullary nailing can be beneficial.
Type II fractures extend proximally into the greater trochanter and
involve the piriformis fossa; this involvement complicates closed
intramedullary nailing techniques. |
 |
Treatment
Treatment options for subtrochanteric
fractures include nonoperative and operative methods. However, as with
intertrochanteric and femoral neck fractures, the mainstay of treatment is
surgery. The goal of treatment is fracture reduction so that near anatomic
alignment and normal femoral anteversion are obtained. One option involves use
of an intramedullary nail with interlocking hardware that extends into the
femoral neck. Another option involves a fixed angle extramedullary device,
such as a 95-degree lag screw and side plate or blade plate (Figure 8).
The screw and side plate and blade plate have
been shown to have high rates of fracture union when used with fractures
involving the piriformis fossa, but intramedullary nails have been
recommended if the posteromedial cortical buttress cannot be established
in unstable fractures.3 It has also
be suggested that the fixed angle extramedullary devices do not allow
compression at the fracture site3; however, with the use of a plate
tensioning device, this can be overcome.
After fracture
fixation, the patient usually requires protected weight bearing for 6 to 12
weeks, and as callous formation is observed radiographically, weight bearing
is slowly increased. Operative treatment allows for immediate mobilization and
pain management and decreases the risk of complications such as skin
breakdown, DVT, and pulmonary abnormalities. |
|
Figure 8. Radiograph (anteroposterior
view) of a sub-trochanteric fracture treated by way of internal fixation
with a blade plate. |
GREATER TROCHANTERIC
FRACTURES
General
Characteristics
The greater trochanter
is the insertion site of the gluteus medius and gluteus minimus (which aid in
hip abduction) and the insertion site of the piriformis, obturator internus,
and gemelli muscles (which aid in hip rotation) (Figure 1).
Classification
There are 2 common
types of greater trochanteric fractures. The first and most common is avulsion
of the greater trochanteric apophysis of the femur, which occurs in skeletally
immature patients.13 This fracture usually occurs from a powerful
muscle contraction of the lateral hip rotators and is usually minimally
displaced.13 The second type of greater trochanteric fracture
usually occurs in an elderly patient who has osteoporosis and results from
direct trauma, such as a fall.3 These fractures are most commonly
minimally displaced, but the portion of the bone attached to the piri-formis
muscle can be markedly displaced.
Treatment
Both types of fracture
can be treated conservatively with protected weight bearing on the affected
leg until the symptoms resolve.3,13 However, a nondisplaced greater
trochanteric fracture that results from a fall needs to be evaluated to
confirm that the fracture does not extend into the intertrochanteric region,
which could result in displacement of the fracture. To evaluate the
fracture, limited MRI3 or a bone scan may be useful. If the
trochanteric fracture involves a large, completely displaced, and mechanically
significant fragment of bone,
it may require reduction and fixation. Screws, cable
devices, and tension band techniques have all been advocated in such cases to
reattach the insertion site of the hip abductors and hip rotators to the
proximal femur.
PROGNOSIS OF
PROXIMAL FEMORAL FRACTURES
Most of the studies
evaluating the prognosis of proximal fractures of the femur compare
intertrochanteric fractures with femoral neck fractures. In the surgical
treatment of intertrochanteric fractures, “cut out” of the implanted hardware
is a preventable complication. However, following surgery, loss of fixation of
any type is less than 15% for both intertrochanteric and femoral neck
fractures.1 Other complications of surgical treatment of proximal
femoral fractures, such as nonunion and osteonecrosis, occur more often with
femoral neck fractures than with intertrochanteric fractures.1
Complications that occur with hemiarthroplasty for femoral neck fractures
include dislocation of the prosthesis in addition to prosthesis loosening. The
dislocation rate is related to technique, but the overall incidence is low and
can be decreased with strict hip-movement precautions taught to the patient by
the physical and occupational therapists.
Hospital stays
tend to be longer for patients with intertrochanteric fractures, as opposed to
femoral neck fractures; likewise, a higher portion of patients with
intertrochanteric fractures require placement in a nursing home.2
Furthermore, although the overall 1-year mortality rate is the same among
patients with inter-trochanteric fractures and those with femoral neck
fractures, patients with intertrochanteric fractures have a slower recovery
rate and a higher mortality rate in the hospital at 2 months and at 6 months.2
Elderly men are
twice as likely to die soon after a hip fracture than are elderly women. In a
study of 804 community-dwelling patients, 31% of the men died within 1 year of
sustaining a hip fracture and 42% within 2 years.33 In comparison,
only 15% of the women in the study died within 1 year and 23% within 2 years.33
PREVENTION OF HIP
FRACTURES
Recovery from a hip
fracture is complex and multidimensional: substantial losses in contralateral
hip bone mineral content, lean body mass, and performance and function are not
fully rectified in most cases. Therefore, prevention is important, especially
for an aging population. By 2020 the estimated number of proximal femoral
fractures expected to occur in the United States is 350,000 per year—and by
2040, between 530,000 and 840,000 fractures are expected to occur.2
Two preventive
strategies to deal with this epidemic are the use of passive protective
garments and prevention and treatment of osteoporosis. Passive protection
through the use of hip pads has recently been demonstrated, and a gel pad with
a rigid cover has been shown to diminish the impact of falls.34
Current research is focusing on who should wear these garments and the best
way to increase patient comfort and compliance.
The prevention and
treatment of osteoporosis may significantly decrease the risk for hip
fracture. It is particularly important to address this issue with respect to
all elderly patients being treated for their first hip fracture. The incidence
of hip fractures is increased among women older than 60 years who have
sustained a hip fracture in the past. Bone mineral density measured at the
femoral neck by dual energy x-ray absorptiometry may be the best predictor of
hip fracture. Awareness of osteoporosis and a multifaceted team approach to
osteoporosis prevention and treatment are the best strategy to prevent
fractures.
CONCLUSION
Hip fracture is a
common and debilitating injury necessitating hospital admission. The hospital
physician should have a clear understanding of the scope of this problem, as
well as the basic types of fracture and treatment options. The care and
rehabilitation of elderly patients with hip fractures raise social and
economic issues that extend beyond orthopaedic management and involve many
different parts of the health care team.
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